Benchtop factory for cross-coupling reactions by circulatory catalyst flow using low-viscosity ionic liquid as reaction medium and catalyst support

Benchtop factory for cross-coupling reactions by circulatory catalyst flow using low-viscosity ionic liquid as reaction medium and catalyst support

Blog Article

This article describes the development of a circulatory catalyst flow system for Pd-catalyzed cross-coupling reactions, such as the Mizoroki-Heck reaction and the Sonogashira reaction, in which low-viscosity ionic liquids such as [bmim]NTf2 and [emim]NTf2 were used as a recyclable reaction medium and a catalyst support.A benchtop production system consisting bovi-shield gold fp 5 l5 of a flow reactor (micromixer plus residence time unit), a dual extraction unit with two T-shaped micromixers, and a catalyst/solvent pumping back system has been designed and tested for a 100 g scale synthesis using the Mizoroki-Heck reaction, fp9550bk which indeed worked well.Using a similar continuous-flow equipment, 103 g of the key intermediate of the matrix metalloproteinase inhibitor was synthesized by Cu-free Sonogashira reaction with [emim]NTf2 as a solvent, in which the system was run for 5.

5 h.The attributes of facile separation and recycling of both the catalyst and the ionic liquid reaction medium impart certain characteristics of heterogeneous catalysis to this continuous-flow system.